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Brain, Vol. 109, No. 4, 759-769, 1986
© 1986 Guarantors of Brain

research-article

REMODELLING OF NERVE STRUCTURE IN EXPERIMENTAL ISONIAZID NEUROPATHY IN THE RAT

W. BEUCHE and R. L. FRIEDE

Department of Neuropathology, University of Gottingen, Federal Republic of Germany

Correspondence to: Correspondence to: Professor R. L. Friede, Abteilung fur Neuropathologie, Universitat Gottingen, Robert-Koch-Strasse 40, D-3400 Gottingen, FRG

SUMMARY

The neuropathy caused by a single dose of isoniazid in rats was studied with a computer-assisted morphometric method. Scatter diagrams of the g ratio (quotient fibre diameter/axon diameter) define regenerating fibres as a distinct population, distinguishable from the surviving fibres by reduced sheath thickness and reduced axon calibre. There was also evidence of a subtle direct toxic effect on the entire fibre population, causing axon shrinkage masked by readjustment of the myelin sheath.

Received September 12, 1985. Revised November 20, 1985. Accepted December 6, 1985.


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