Brain, Vol. 125, No. 11, 2460-2468,
November 2002
© 2002 Oxford University Press
Pure optic-spinal form of multiple sclerosis in Japan
1 Department of Neurology, Tohoku University School of Medicine and 2 Department of Neurology, Konan Hospital, Sendai, Japan
Correspondence to: T. Misu, Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai 980-8574, Japan E-mail: misu{at}neurol.med.tohoku.ac.jp
We evaluated the clinical and laboratory features of the optic-spinal form of multiple sclerosis (OSMS) with no brain lesions on repeated MRI—termed pure OSMS. By reviewing the medical records of 118 Japanese clinically definite multiple sclerosis patients seen between 1988–1999, we found 10 patients (8.5%), nine of whom were women, with only relapsing optic neuritis (ON) and myelitis (MY) clinically and consistently normal brain MRI during follow-ups of 
5 years. Three patients suffered severe ON and MY, but the other seven had mild disease (six were graded 1 in the Disability Status Scale). Despite frequent relapses, mild pure OSMS was characterized by younger onset and mild spinal symptoms as in ‘benign’ classical multiple sclerosis (CMS). MRI often revealed multiple cervico-thoracic cord lesions of variable lengths. Oligoclonal IgG bands (OB) were negative in all cases. HLA-DPB1*0501, whose association with OSMS has been reported, was positive only in six patients (including three patients with severe pure OSMS). Four patients with DRB1*1501-DQB1*0602, to which CMS is closely linked, had mild disease. Though pure OSMS was heterogeneous with regard to clinical severity and human leukocyte antigen (HLA) class II alleles, this form of multiple sclerosis was characterized by a definite female preponderance and negative OB that distinguished it from CMS.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Tanaka, K. Tanaka, M. Komori, and T. Saida Anti-aquaporin 4 antibody in Japanese multiple sclerosis: the presence of optic spinal multiple sclerosis without long spinal cord lesions and anti-aquaporin 4 antibody J. Neurol. Neurosurg. Psychiatry, September 1, 2007; 78(9): 990 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Watanabe, T. Misu, I. Miyazawa, I. Nakashima, Y. Shiga, K. Fujihara, and Y. Itoyama Low-dose corticosteroids reduce relapses in neuromyelitis optica: a retrospective analysis Multiple Sclerosis, September 1, 2007; 13(8): 968 - 974. [Abstract] [PDF]
|
|
|
|
 |
|
 C. S. Yu, C. Z. Zhu, K. C. Li, Y. Xuan, W. Qin, H. Sun, and P. Chan Relapsing Neuromyelitis Optica and Relapsing-Remitting Multiple Sclerosis: Differentiation at Diffusion-Tensor MR Imaging of Corpus Callosum Radiology, July 1, 2007; 244(1): 249 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. Weinshenker Neuromyelitis Optica Is Distinct From Multiple Sclerosis Arch Neurol, June 1, 2007; 64(6): 899 - 901. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Misu, K. Fujihara, A. Kakita, H. Konno, M. Nakamura, S. Watanabe, T. Takahashi, I. Nakashima, H. Takahashi, and Y. Itoyama Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis Brain, May 1, 2007; 130(5): 1224 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nakamura, I. Nakashima, S. Sato, I. Miyazawa, K. Fujihara, and Y. Itoyama Clinical and laboratory features of neuromyelitis optica with oligoclonal IgG bands Multiple Sclerosis, April 1, 2007; 13(3): 332 - 335. [Abstract] [PDF]
|
|
|
|
 |
|
 E. BETTELLI Building Different Mouse Models for Human MS Ann. N.Y. Acad. Sci., April 1, 2007; 1103(1): 11 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Fukazawa and S Kikuchi A three-dimensional approach for understanding the spectrum of idiopathic inflammatory demyelinating disorders: importance of the 'attack-related severity' axis Multiple Sclerosis, March 1, 2007; 13(2): 199 - 207. [Abstract] [PDF]
|
|
|
|
|
|
J. A Cabrera-Gomez, L Quevedo-Sotolongo, A Gonzalez-Quevedo, S Lima, Y Real-Gonzalez, M Cristofol-Corominas, K Romero-Garcia, C Ugarte-Sanchez, J Jordan-Gonzalez, J E G. de la Nuez, et al. Brain magnetic resonance imaging findings in relapsing neuromyelitis optica Multiple Sclerosis, March 1, 2007; 13(2): 186 - 192. [Abstract] [PDF]
|
|
|
|
|
|
S Watanabe, I Nakashima, T Misu, I Miyazawa, Y Shiga, K Fujihara, and Y Itoyama Therapeutic efficacy of plasma exchange in NMO-IgG-positive patients with neuromyelitis optica Multiple Sclerosis, January 1, 2007; 13(1): 128 - 132. [Abstract] [PDF]
|
|
|
|
|
|
I Nakashima, K Fujihara, I Miyazawa, T Misu, K Narikawa, M Nakamura, S Watanabe, T Takahashi, S Nishiyama, Y Shiga, et al. Clinical and MRI features of Japanese patients with multiple sclerosis positive for NMO-IgG J. Neurol. Neurosurg. Psychiatry, September 1, 2006; 77(9): 1073 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Fukazawa, S Kikuchi, R Miyagishi, Y Miyazaki, I Yabe, T Hamada, and H Sasaki HLA-DPB1*0501 is not uniquely associated with opticospinal multiple sclerosis in Japanese patients. Important role of DPB1*0301 Multiple Sclerosis, February 1, 2006; 12(1): 19 - 23. [Abstract] [PDF]
|
|
|
|
|
|
M Nakamura, M Endo, K Murakami, H Konno, K Fujihara, and Y Itoyama An autopsied case of neuromyelitis optica with a large cavitary cerebral lesion Multiple Sclerosis, December 1, 2005; 11(6): 735 - 738. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Misu, K. Fujihara, I. Nakashima, S. Sato, and Y. Itoyama Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica Neurology, November 8, 2005; 65(9): 1479 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. Lennon, T. J. Kryzer, S. J. Pittock, A.S. Verkman, and S. R. Hinson IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel J. Exp. Med., August 15, 2005; 202(4): 473 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F Scott, S. L Kassab, and S. Singh Acute partial transverse myelitis with normal cerebral magnetic resonance imaging: transition rate to clinically definite multiple sclerosis Multiple Sclerosis, August 1, 2005; 11(4): 373 - 377. [Abstract] [PDF]
|
|
|
|
|
|
H. Sakuma, K. Kohyama, I.-K. Park, A. Miyakoshi, N. Tanuma, and Y. Matsumoto Clinicopathological study of a myelin oligodendrocyte glycoprotein-induced demyelinating disease in LEW.1AV1 rats Brain, October 1, 2004; 127(10): 2201 - 2213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takahashi, T. Aranami, M. Endoh, S. Miyake, and T. Yamamura The regulatory role of natural killer cells in multiple sclerosis Brain, September 1, 2004; 127(9): 1917 - 1927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Pradhan and V N Mishra A central demyelinating disease with atypical features Multiple Sclerosis, June 1, 2004; 10(3): 308 - 315. [Abstract] [PDF]
|
|
|
|
|
|
I. Nakashima, K. Fujihara, J. Fujimori, K. Narikawa, T. Misu, and Y. Itoyama Absence of IgG1 response in the cerebrospinal fluid of relapsing neuromyelitis optica Neurology, January 13, 2004; 62(1): 144 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-k. Kim Idiopathic Recurrent Transverse Myelitis Arch Neurol, September 1, 2003; 60(9): 1290 - 1294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Characterizing Pure Opticospinal Multiple Sclerosis Journal Watch Neurology, January 10, 2003; 2003(110): 5 - 5. [Full Text]
|
|