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Brain Advance Access originally published online on August 2, 2004
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Brain, Vol. 127, No. 9, 1958-1969, September 2004
© 2004 Guarantors of Brain
doi: 10.1093/brain/awh214

Impaired recognition of anger following damage to the ventral striatum

Andrew J. Calder1, Jill Keane1, Andrew D. Lawrence1 and Facundo Manes2

1 MRC Cognition and Brain Sciences Unit, Cambridge, UK and 2 Cognitive and Behavioral Neurology Section, Department of Neurology, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina

Correspondence to: Andrew Calder, MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK E-mail: andy.calder{at}mrc-cbu.cam.ac.uk

Comparative neuropsychology has identified a role for the ventral striatum (VS) in certain forms of aggression. To address whether the homologous region in humans also contributes to the emotion anger, we studied a case series of four human subjects with focal lesions affecting the VS. All four demonstrated a disproportionate impairment in recognizing human signals of aggression. By contrast, a control group of individuals with damage to more dorsal basal ganglia (BG) regions showed no evidence of an anger impairment. Our findings demonstrate that the VS makes a significant contribution to coding signals of aggression in humans, and emphasize the importance of an approach to human affective neuroscience based on cross-species homologies. The results are discussed in relation to the ventral striatal dopamine system's role in the pursuit of biological resources in general. We propose that the role of the VS in the recognition of human signals of anger may reflect a more general role in the coordination of behaviour relevant to the acquisition and protection of valued resources, including detection of signals of conspecific challenge (anger).


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