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Brain, Vol. 122, No. 2, 181-182, February 1999
© 1999 Oxford University Press

Editorial

Metalloproteinases and specific inhibitors in multiple sclerosis: from blood to brain or vice versa?

G. Opdenakker

Rega Institute for Medical Research, University of Leuven, Belgium

During the last two decades the understanding of the molecular basis of antigen capture, processing, presentation and recognition has grown enormously, and it is everyone's hope that the knowledge of specific tolerance induction, molecular mimicry, epitope spreading and auto-antibody formation will be translated into better treatments for autoimmune diseases. However, if one examines current treatments with proven usefulness in multiple sclerosis e.g. corticosteroids, ß-interferon and copolymer-1, it can be seen that these are all indirectly linked to the above concepts and are nonspecific immunologically. This observation is important for the multiple sclerosis society because it should not only catalyse further research into . . . [Full Text of this Article]

In vivo veritas

L'union fait la force

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