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Brain, Vol. 123, No. 1, 189-190, January 2000
© 2000 Oxford University Press

Book reviews

BRAIN TUMOUR INVASION; BIOLOGICAL, CLINICAL AND THERAPEUTIC CONSIDERATIONS.

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Dr John L. Darling

University Department of Neurosurgery, Institute of Neurology, University College, National Hospital for Neurology and Neurosurgery, London, UK

There is little doubt that diffuse invasion of isolated tumour cells long distances within the brain is the major obstacle to clinical therapy of many types of human malignant brain tumour. This is epitomized by glioblastoma multiforme, where it was recognized as early as the second decade of this century by Dandy that cure through massive surgical resection was doomed to failure. Even complete hemispherectomies failed to produce clinical cures, with tumour invariably recurring in the contralateral hemisphere as a result of widespread diffuse invasion of tumour cells by the time of diagnosis. However, glioblastoma multiforme provides . . . [Full Text of this Article]

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