Brain, Vol. 123, No. 3, 423-424,
March 2000
© 2000 Oxford University Press
Editorial |
Unravelling the pathophysiology of calcium channel mutations causing neurological disorders
Fédération de Neurologie and INSERM CJF9711, Faculté de Médecine Pitié-Salpêtrière, Paris, France
Voltage-gated calcium channels are molecules that play a key role in cell-to-cell communication and muscle contraction. They are divided into low voltage-activated (LVA or T-type) and high voltage-activated (HVA) channels, which may further be dissected into L, N, P/Q and R channels based on their sensitivity to drugs and toxins. Calcium channels constitute a heteromeric complex composed of a large pore-forming
1 subunit and four
References