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Brain 2008 131(5):1165-1167; doi:10.1093/brain/awn073
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© The Author (2008). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Brain stem encephalitis and the syndrome of Miller Fisher. A clinical study. By Amir Najim Al-Din, Milne Anderson, Edwin R. Bickerstaff and Ian Harvey (From the Midland Centre for Neurosurgery, Smethwick, West Midlands, UK). Brain 1982: 105; 481—495; and Bickerstaff's brainstem encephalitis: clinical features of 62 cases and a subgroup associated with Guillain-Barré syndrome. By Masaaki Odaka, Nobuhiro Yuki, Mitsunori Yamada, Michiaki Koga, Toshihiko Takemi, Koichi Harata and Satoshi Kuwabara (From the University School of Medicine, Tochigi; Brain Research Institute, Niigata University; St Luke's International Hospital, Toyko; and Chiba University School of Medicine, Chiba, Japan) Brain 2003: 126; 2279–2290.

Alastair Compston

Cambridge

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In 1957, Edwin Bickerstaff (1920–2007) followed up on three cases of mesencephalitis and rhomboencephalitis he had reported 6 years earlier with Philip Cloake (1890–1969), describing as a definitive syndrome eight patients with acute symmetrical ophthalmoplegia, other cranial nerve palsies and ataxia (Br Med J 1957: 1; 1384–1387). The team from Birmingham opens their new analysis of this disorder by stating unambiguously that ‘brainstem encephalitis includes the syndrome of ophthalmoplegia, ataxia and hyporeflexia’. The typical form is characterized by acute progressive ophthalmoplegia, involvement of other cranial nerves, ataxia and hyporeflexia, no significant motor or sensory deficit in the limbs and usually with full recovery. After the appearance of Charles Miller Fisher's paper in 1956 (New Engl J Med 1956: 255; 57–65) in which, reporting three cases and building on the suggestion by James Collier (1870–1935) that the Guillain–Barré syndrome may show external ophthalmoplegia with or without limb paralysis and . . . [Full Text of this Article]


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