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Brain Advance Access originally published online on June 21, 2008
Brain 2008 131(7):1677-1680; doi:10.1093/brain/awn130
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© The Author (2008). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The problem of disseminated sclerosis (being the Presidential Address of the Neurological Section, Royal Society of Medicine, October 1946). By Douglas McAlpine. Brain 1946: 69; 233–250.

Alastair Compston

Cambridge

The first 150 words of the full text of this article appear below.

Quite when Douglas McAlpine (see Figure) became interested in the problem of disseminated sclerosis is unclear. He worked originally on encephalitis lethargica but published on demyelinating disease from 1931, first speculating that acute disseminated encephalomyelitis and disseminated sclerosis are caused by specifically different virus infections, the former being self-limited because immunity is conferred by the initial attack (Lancet 1931: 1; 846–52). In 1938, he wrote on concordance for neuromyelitis optica in a pair of identical twins (Brain 1938: 61; 430–48). The monograph on Multiple Sclerosis written with Charles Lumsden and Nigel Compston in 1955 has a concluding chapter on the problem of causation where ideas are developed on the aetiology and pathogenesis: ‘a study of the natural history suggests that more attention should be focused on the genetic and allergic backgrounds of the disease ... [and the role of] ... some so far unidentified factor with selective affinity . . . [Full Text of this Article]


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