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Cover design Neural precursor cells propagated in vitro with epidermal growth factor adopt astrocytic and oligodendroglial phenotypes following intracerebroventricular transplantation in neonatal mice. Engrafted cells genetically labelled with green fluorescent protein (left panels) co-express immunoreactive glial fibrillary acidic protein, an intermediate filament protein of astroglia (red in top right panel for cell in top left), or 2€,3€-cyclic nucleotide 3€-phosphodiesterase, an enzymatic component of myelin membrane (red in bottom right panel for cell in bottom left). In myelin-deficient shiverer hosts, transplanted cells disseminate widely and begin to myelinate central white matter tracts throughout the brain. From `Towards the reconstruction of central nervous system white matter using neural precursor cells' by M. Mitome et al., 21472161.
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